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- Secondary antibodies
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Read our guarantee »Overview
Product name
Anti-VEGFR 1+VEGFR 2 antibody
Description
Rabbit polyclonal to VEGFR 1+VEGFR 2
Specificity
This antibody is specific for VEGFR 1 with significant cross-reactivity with the VEGFR 2 protein.
Tested applications
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide, corresponding to amino acids 800-900 of Mouse VEGFR 1.
Positive control
HUVEC lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.05% Sodium Azide
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
ab36844 is an affinity purified IgG.
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolism processes >> Hypoxia
Cancer >> Cancer Metabolism >> Response to hypoxia
Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Growth factor receptors
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic growth factors
Cancer >> Growth factors >> VEGF
Signal Transduction >> Growth Factors/Hormones >> VEGF
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Src Family
Cardiovascular >> Angiogenesis >> Growth Factors >> VEGF >> VEGF Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab36844 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/250 - 1/1000. Predicted molecular weight: 150 kDa.
Target
Relevance
Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
Cellular localization
Cell Membrane
Alternative names
- Embryonic receptor kinase 2 antibody antibody
- Fetal liver kinase 1 antibody antibody
- FLK1 antibody
see all
Database links
- Entrez Gene: 2321 Human
- Entrez Gene: 3791 Human
- Entrez Gene: 14254 Mouse
- Entrez Gene: 16542 Mouse
- Omim: 165070 Human
- Omim: 191306 Human
- SwissProt: P17948 Human
- SwissProt: P35968 Human
see all
References for Anti-VEGFR 1+VEGFR 2 antibody (ab36844)
ab36844 has not yet been referenced specifically in any publications.
Publishing research using ab36844? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"