VIP antibody (ab8556)

Product Name 

VIP antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to VIP

Immunogen 

Synthetic peptide.

Reacts with 
(species key)

Hu

Specificity 

This antibody reacts with a 3 kD vasointestinal peptide (VIP) localized in nerve fibers in the central and peripheral nervous system.
The VIP producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.

Tested applications 
(see key)

IHC-FoFr, IHC-Fr, IHC-P

Abreviews 

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Application notes 
(see key)

Recommended dilutions
For paraffin-embedded tissue sections, we recommend a dilution of 1:20
The optimal conditions should be determined by the individual laboratory
This antibody does not require heat mediated antigen retrieval

Cellular localization 

Secreted

Research areas 

Neuroscience >> Neurotransmitter >> Neuropeptides >> Hormones

Relevance 

Vasoactive Intestinal Peptide (VIP), a 28 amino acid peptide originally isolated from porcine duodenum, is present not only in gastrointestinal tissues but also in neural tissues, possibly as a neurotransmitter, and exhibits a wide variety of biological actions. It belongs to the glucagon family, and in the duodenum is known to stimulate myocardial contractility, cause vasodilation, increase glycogenolysis, lower arterial blood pressure and relax the smooth muscle of trachea, stomach and gall bladder. Ectopic endocrine tumors secreting VIP (VIPomas) give rise to raised plasma levels of VIP and are associated with watery diarrhea, hypokalemia and achlorhydria syndrome.

This antibody detects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Purity 

Preadsorbed antiserum

Storage buffer 

0.02M sodium phosphate, 0.1M sodium chloride, pH 7.3 and 0.05% sodium azide.

Material safety datasheets (MSDS) for this product:
Sodium Azide MSDS
Sodium Phosphate MSDS

Purification notes 

After solid-phase absorption this antibody is filtered through a 0.22 µm filter, vialed and lyophilized.

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C. Do not freeze.

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