Verapamil hydrochloride, L-type Ca2+ channel blocker (ab120140)
Key features and details
- L-type Ca2+ channel blocker
- CAS Number: 152-11-4
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Verapamil hydrochloride, L-type Ca2+ channel blocker -
Description
L-type Ca2+ channel blocker -
Biological description
L-type Ca2+ channel blocker. Antiarrhythmic in vivo.
Also available in simple stock solutions (ab146680) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
152-11-4 -
Chemical structure
Properties
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Chemical name
5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride -
Molecular weight
491.06 -
Molecular formula
C27H38N2O4.HCl -
PubChem identifier
62969 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.COc1cc(ccc1OC)C(C#N)(CCCN(C)CCc2ccc(OC)c(OC)c2)C(C)C -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120140 has been referenced in 3 publications.
- Šrámek J et al. Calcium channel blockers do not protect against saturated fatty acid-induced ER stress and apoptosis in human pancreatic ß-cells. Nutr Metab (Lond) 18:74 (2021). PubMed: 34274001
- Kobuszewska A et al. Heart-on-a-Chip: An Investigation of the Influence of Static and Perfusion Conditions on Cardiac (H9C2) Cell Proliferation, Morphology, and Alignment. SLAS Technol 22:536-546 (2017). PubMed: 28430559
- Silswal N et al. Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction. Am J Physiol Heart Circ Physiol 300:H2016-26 (2011). PubMed: 21421826