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Anti-Vesicle docking protein p115 antibody (ab74867)

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Overview

Product name

Anti-Vesicle docking protein p115 antibody
See all Vesicle docking protein p115 products (6) ...

Description

Sheep polyclonal to Vesicle docking protein p115

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide from the internal part of human Vesicle docking protein p115 conjugated to an immunogenic carrier protein. The antigen is homologous in rat and mouse.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Protein Trafficking >> Golgi Proteins
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Adapters

Applications

Show applications key

Our Abpromise guarantee covers the use of ab74867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IHC-P

     

  • IHC-Fr

     

Application notes

IHC-P: 1/300 - 1/3000. Antigen retrieval is recommended.
IHC-Fr: 1/300 - 1/3000.
WB: 1/300 - 1/3000. Predicted molecular weight: 108 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.

Sequence similarities

Belongs to the VDP/USO1/EDE1 family.
Contains 10 ARM repeats.

Domain

Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain.

Post-translational
modifications

Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.

Cellular localization

Cytoplasm > cytosol. Golgi apparatus membrane. Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.

Target information above from: UniProt accessionO60763 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • General vesicular transport factor antibody
  • General vesicular transport factor p115 antibody
  • P115 antibody
  • Protein USO1 homolog antibody
  • TAP antibody
  • Transcytosis associated protein antibody
  • Transcytosis-associated protein antibody
  • Uso1 antibody
  • USO1_HUMAN antibody
  • VDP antibody
  • Vesicle docking protein antibody
  • Vesicle-docking protein antibody
see all

Database links

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References for Anti-Vesicle docking protein p115 antibody (ab74867)

ab74867 has not yet been referenced specifically in any publications.

Publishing research using ab74867? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"