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Read our guarantee »Overview
Product name
Vigabatrin
Description
Irreversible inhibitor of GABA transaminase
Alternative names
- γ-Vinyl-GABA
Biological description
Irreversible inhibitor of GABA transaminase (GABA-T). Increases GABA concentrations in the brain. Anticonvulsant and induces neuronal plasticity in mouse models.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
4-Amino-5-hexenoic acid
Molecular Weight
129.16
Chemical structure
Molecular formula
C6H11NO2
CAS Number
60643-86-8
Solubility
Soluble in water to 100 mM
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Transaminase >> Inhibitors
Biochemicals >> Pharmacology >> Receptors & Transporters >> GABA >> Other
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Chemical Type >> Amino Acid
Biochemicals >> Product Range >> Just Add Water
References for Vigabatrin (ab120310)
This product has been referenced in:
- Wang QP et al. Treatment of epilepsy: the GABA-transaminase inhibitor, vigabatrin, induces neuronal plasticity in the mouse retina. Eur J Neurosci 27:2177-87 (2008).Read more (PubMed: 18412635) »
- Duboc A et al. Vigabatrin, the GABA-transaminase inhibitor, damages cone photoreceptors in rats. Ann Neurol 55:695-705 (2004).Read more (PubMed: 15122710) »
See all 3 publications for this product
Publishing research using ab120310? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"