Anti-Vitamin D Binding protein antibody [2G2] (ab23480)
Overview
- Product nameAnti-Vitamin D Binding protein antibody [2G2]See all Vitamin D Binding protein primary antibodies ...
- DescriptionMouse monoclonal [2G2] to Vitamin D Binding protein
- Specificityab23480 is specific for Gc-globulin (vitamin D binding protein).
- Tested applicationsELISA, WB more details
- Species reactivityReacts with: Human
- Immunogen
Full length native Gc-globulin isolated from human plasma
- Positive controlHuman plasma can be used as a positive control. The concentration of Gc-globulin in human plasma is approximately 400 µg/ml.
Properties
- FormLiquid
- Storage instructionsStore at +4°C in the dark.
- Storage bufferPreservative: 15mM Sodium Azide
Constituents: 500mM Sodium chloride, 10mM PBS, pH 7.4 -
Concentration information loading... - PurityProtein A purified
- Clonality Monoclonal
- Clone number2G2
- Myelomax63-Ag8.653
- IsotypeIgG1
- Light chain typekappa
-
Research Areas
Applications
Our Abpromise guarantee covers the use of ab23480 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ELISA | ELISA: 1/20000. |
| WB | WB: Use at an assay dependent dilution. Detects a band of approximately 50 kDa. (Note: In Western blotting after SDS-PAGE, HYB 249-01 reacts with Gc-globulin in both reduced as well as unreduced forms.) |
Target
- FunctionMultifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
- Sequence similaritiesBelongs to the ALB/AFP/VDB family.
Contains 3 albumin domains. - Cellular localizationSecreted.
-
Database links
- Entrez Gene: 2638 Human
- Omim: 139200 Human
- SwissProt: P02774 Human
- Unigene: 418497 Human
Target information above from: UniProt accession
P02774
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
.
-
Alternative names
- DBP antibodyDBP/GC antibodyGC antibody
- Gc globulin antibodyGc-globulin antibodyGRD3 antibodyGroup specific component antibodyGroup specific component vitamin D binding protein antibodyGroup-specific component antibodyhDBP antibodyVDB antibodyVDBG antibodyVDBP antibodyVitamin D binding alpha globulin antibodyVitamin D-binding protein antibodyVTDB_HUMAN antibody
see all
References for Anti-Vitamin D Binding protein antibody [2G2] (ab23480)
This product has been referenced in:
- Pottiez G et al. Plasma proteomic profiling in HIV-1 infected methamphetamine abusers. PLoS One 7:e31031 (2012). WB ; Human . Read more (PubMed: 22359561) »
- Bai S et al. Proteome analysis of biomarkers in the cerebrospinal fluid of neuromyelitis optica patients. Mol Vis 15:1638-48 (2009). WB ; Human . Read more (PubMed: 19710940) »
