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Anti-Vitronectin antibody [BV1] (ab7165)

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Overview

Product name

Anti-Vitronectin antibody [BV1]
See all Vitronectin products (12) ...

Description

Mouse monoclonal [BV1] to Vitronectin

Specificity

The antibody binds to soluble vitronectin as well as to membrane bound vitronectin.

Tested applications

IHC-P, WB, IP, IF, Purificationmore details

Cross reactivity

Reacts with

Human

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

PBS with 0.2% BSA, 0.1% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

BV1

Isotype

IgG1

Research areas

Immunology >> Innate Immunity >> Complement >> Regulatory
Cardiovascular >> Blood >> Serum Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab7165 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Tissue specificity

Plasma.

Sequence similarities

Contains 4 hemopexin-like domains.
Contains 1 SMB (somatomedin-B) domain.

Domain

The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.

Post-translational
modifications

Sulfated on 2 tyrosine residues.
N- and O-glycosylated.
Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Phosphorylation sites are present in the extracelllular medium.

Cellular localization

Secreted > extracellular space.

Target information above from: UniProt accessionP04004 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Complement S Protein antibody
  • Epibolin antibody
  • S Protein antibody
  • S-protein antibody
  • Serum Spreading Factor antibody
  • Serum-spreading factor antibody
  • Somatomedin B antibody
  • Somatomedin-B antibody
  • V75 antibody
  • Vitronectin V10 subunit antibody
  • Vitronectin V65 subunit antibody
  • VN antibody
  • VNT antibody
  • VTN antibody
  • VTNC_HUMAN antibody
see all

Database links

References for Anti-Vitronectin antibody [BV1] (ab7165)

This product has been referenced in:

  • Knappe UJet al. Expression of extracellular matrix-proteins in perisellar connective tissue and dura mater. Acta Neurochir (Wien) 152:345-53 (2010). IHC-P; Human.Read more (PubMed: 19730772) »

See 1 publication for this product

Publishing research using ab7165? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"