Vitronectin antibody [BV1] (ab7165)

Product Name 

Vitronectin antibody [BV1]

Product type 

Primary antibodies

Description 

Mouse monoclonal [BV1] to Vitronectin

Reacts with 
(species key)

Hu

Specificity 

The antibody binds to soluble vitronectin as well as to membrane bound vitronectin.

Tested applications 
(see key)

ICC/IF, IP, P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IF: Use at an assay dependent concentration.
IP: Use at an assay dependent concentration.
P: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted, Extracellular

Research areas 

Immunology >> Innate Immunity >> Complement >> Regulatory
Cardiovascular >> Blood >> Serum Proteins

Relevance 

Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

BV1

Isotype 

IgG1

Purity 

IgG fraction

Storage buffer 

PBS with 0.2% BSA, 0.1% sodium azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.100 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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