Anti-Vitronectin antibody (ab20091)

Overview

• Product nameAnti-Vitronectin antibodySee all Vitronectin primary antibodies ...
• Description
  Rabbit polyclonal to Vitronectin
• SpecificityReacts with both native monomeric and polymeric vitronectin in various tissues and plasma.
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Full length native protein (Human).

• General notesThe concentration of this product is lot-specific.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 0.1M Sodium chloride, 0.05M Sodium phosphate, 1mM EDTA. pH 6.6
• Concentration information loading...
• PurityProtein A purified
• Purification notes>98% pure (SDS-PAGE).
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Immunology
  • Innate Immunity
  • Complement
  • Regulatory

Applications

Target

• FunctionVitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
  Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
• Tissue specificityPlasma.
• Sequence similaritiesContains 4 hemopexin-like domains.
  Contains 1 SMB (somatomedin-B) domain.
• DomainThe SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.
• Post-translational
  modificationsSulfated on 2 tyrosine residues.
  N- and O-glycosylated.
  Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.
  It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  Phosphorylation sites are present in the extracellular medium.
• Cellular localizationSecreted > extracellular space.

Target information above from: UniProt accession P04004 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7448 Human
  • Omim: 193190 Human
  • SwissProt: P04004 Human
  • Unigene: 2257 Human

• Alternative names
  Complement S Protein antibodyEpibolin antibodyS Protein antibody

  S-protein antibodySerum Spreading Factor antibodySerum-spreading factor antibodySomatomedin B antibodySomatomedin-B antibodyV75 antibodyVitronectin V10 subunit antibodyVitronectin V65 subunit antibodyVN antibodyVNT antibodyVTN antibodyVTNC_HUMAN antibody

  see all