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Product Name
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Von Willebrand Factor antibody [4F9]
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See all Von Willebrand Factor antibodies (24)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [4F9] to Von Willebrand Factor
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Immunogen
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FVIII: C/vWF complex (denaturated)
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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Flow Cyt, ICC/IF, IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 2µg for 105 cells.
IF: Use 5µg for 105 cells.
IHC-Fr: 1/50 - 1/100.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted. Localized to storage granules.
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Research areas
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Stem Cells >> Endothelial Progenitors >> Endothelial Markers
Cardiovascular >> Blood >> Coagulation >> Regulatory
Cardiovascular >> Blood >> Coagulation >> Extrinsic
Cardiovascular >> Blood >> Platelets
Cardiovascular >> Blood >> Serum Proteins
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Relevance
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Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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4F9
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein A purified
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Storage buffer
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Preservative: None
Constituents: PBS, 1mg/ml BSA
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Von Willebrand Factor antibody [4F9] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Von Willebrand Factor
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