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Product Name
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WWOX antibody
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See all WWOX antibodies (7)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to WWOX
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Immunogen
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Synthetic peptide: RLAFTVDDNPTKPTTRQRY, corresponding to amino acids 89-107 of Human WWOX
BLAST 'RLAFTVDDNPTKPTTRQRY' with  or 
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Reacts with
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Hu, Ms, Rat
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Predicted to react
(species key)
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Chmp, Orngt
(Due to sequence homology)
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Tested applications
(see key)
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ICC/IF, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC/IF: 1/1000.
IP: Use at an assay dependent dilution.
WB: 1/1000 - 1/5000. Predicted molecular weight: 47 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Mouse fibroblast L929 cell line
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Cellular localization
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Cytoplasmic, Golgi Apparatus, Mitochondrial and Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
Cell Biology >> Apoptosis >> Intracellular >> Associated Proteins
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Relevance
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WW domain-containing oxidoreductase WWOX, also known as WOX1 or FOR, is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein A purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this WWOX antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to WWOX
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WWOX antibody - more information
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Customer reviews (feedback) regarding WWOX antibody |
Customer FAQs regarding WWOX antibody |
Protocols for WWOX antibody |
Price and availability of products related to WWOX antibody |
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WWOX antibody - related products:
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WWOX antibody - other tools:
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Contact Abcam with a Technical Enquiry about WWOX antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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