WWOX peptide (ab45233)
- 5330426P09Rik9030416C10RikAberrant WW domain-containing oxidoreductase
- D16S432EEC 1.1.1.-FORFRA16DFragile site FRA16D oxidoreductaseFragile site FRA16D OxireductaseHHCMA56MGC55975PRO0128Putative oxidoreductaseSDR41C1Short chain dehydrogenase/reductase family 41C, member 1WOX1WW domain containing oxidoreductaseWW domain-containing oxidoreductaseWW domain-containing protein WWOXwwoxWWOX_HUMANzgc:55975
Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:133239].
Contains 2 WW domains.
modificationsPhosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation.
Ubiquitinated when phosphorylated by TNK2, leading to its degradation.
References for WWOX peptide (ab45233)
ab45233 has not yet been referenced specifically in any publications.