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Product Name
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XAF1 peptide (305-317)
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide: CEKERYYKFKRFHF, corresponding to C terminal amino acids 305-317 of Human XAF1
BLAST 'CEKERYYKFKRFHF' with  or 
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Tested applications
(see key)
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BL, WB
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Application notes
(see key)
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Recommended dilutions
BL: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.
This peptide can be used with studies using ab17204.
It usually blocks the antibody activity completely in western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Inhibitors
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Relevance
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XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all adult and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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ab39906 is a crude synthetic peptide, purity range from 60-70%. The sequence is proprietary.
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this XAF1 peptide (305-317) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to XAF1
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XAF1 peptide (305-317) - more information
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