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- XBP1 antibody (ab37151)
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Product Name
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XBP1 antibody
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See all XBP1 antibodies (10)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to XBP1
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Immunogen
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Synthetic peptide corresponding to 17 amino acids near to the C terminus of the human XBP1 protein.
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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This product will recognize only the non-spliced (shorter) form of XBP1.
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Tested applications
(see key)
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ICC/IF, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC/IF: Use at a concentration of 2 µg/ml.
WB: Use at a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 34 kDa (predicted molecular weight: 29 kDa). Can be blocked with XBP1 peptide (ab39909).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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PC3 cell lysate.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Transcription >> Transcription Factors
Chromatin and Nuclear Signaling >> Transcription >> Other factors
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Relevance
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This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this XBP1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for XBP1 antibody images, references, products related to ab37151 and other tools.
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XBP1 antibody images:
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 - XBP1 antibody (ab37151)
Western blot analysis of XBP-1 in PC-3 cell lysate with ab37151 at (A) 0.5, (B) 1 and (C) 2 µg/ml.
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References for XBP1 antibody (ab37151)
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This product has been used in:
Gaviln MP et al. Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition. Aging Cell 8:654-65 (2009). WB; Rat. PubMed: 19747230
If you publish research using ab37151 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to XBP1
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XBP1 antibody - more information
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Customer reviews (feedback) regarding XBP1 antibody |
Customer FAQs regarding XBP1 antibody |
Protocols for XBP1 antibody |
Price and availability of products related to XBP1 antibody |
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XBP1 antibody - related products:
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XBP1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about XBP1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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