XIAP antibody (ab21278)

Product Name 

XIAP antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to XIAP

Immunogen 

Synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.

Reacts with 
(species key)

Hu, Ms

Tested applications 
(see key)

IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
IHC-P: Use at a concentration of 2 µg/ml. Antigen retrieval: sodium citrate, 1-5 min heat (microwave).
WB: Use at a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 55 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Human kidney cell lysate.

Cellular localization 

Cytoplasmic

Research areas 

Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> IAPs
Cancer >> Invasion/microenvironment >> Apoptosis >> Caspases
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Inhibitors
Cell Biology >> Apoptosis >> Intracellular >> Survivin / IAPs

Relevance 

The human X chromosome linked Inhibitor of Apoptosis Protein (XIAP) is a major member of the inhibitor of apoptosis (IAP) family. XIAP functions by direct binding and inhibition of several caspases, including Caspase 3, Caspase 7 and Caspase 9. During apoptosis XIAP is specifically cleaved by Caspase 3 and partially loses its function. In addition to blocking the apoptosis signaling pathway, XIAP can also bind several other proteins in the bone morphogenetic protein (BMP) signaling pathway and act as a coupler between the membrane BMP receptor and the TAB1 TAK1 complex by binding to these proteins.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Purified by ion exchange chromatography.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C.

See below for XIAP antibody images, references, products related to ab21278 and other tools.

XIAP antibody images:

References for XIAP antibody (ab21278)

  This product has been used in: (two most recent references)

Groskreutz DJ et al. Cigarette Smoke Alters Respiratory Syncytial Virus-induced Apoptosis and Replication. Am J Respir Cell Mol Biol : (2009). PubMed: 19131644

Ashare A et al. Insulin Like Growth Factor-1 Improves Survival in Sepsis via Enhanced Hepatic Bacterial Clearance. Am J Respir Crit Care Med : (2008). PubMed: 18436791

See all 5 publication references for this product.


If you publish research using ab21278 please let us know so that we can cite the reference on this datasheet.

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