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Product Name
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XPA antibody [5A2]
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See all XPA antibodies (11)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [5A2] to XPA
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Immunogen
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His-tagged recombinant human XPA (Xeroderma Pigmentosum group A) protein
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Reacts with
(species key)
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Hu
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Nucl. Excision Repair
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Relevance
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The XPA (xeroderma pigmentosum group A) protein specifically recognizes the UV- or chemically damaged DNA lesions, and triggers the nucleotide excision repair process. XPA binds to the replication protein A (RPA) or the excision repair cross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer at sun-exposed areas.
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XPA antibody [5A2] (ab44) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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5A2
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Myeloma
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Sp2
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Isotype
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IgG1
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Purity
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Protein A purified
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Storage buffer
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Phosphate buffered saline
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Form
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Liquid
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Concentration
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1.100 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Works on pure and partially purified protein but not on crude cell extract.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this XPA antibody [5A2] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for XPA antibody [5A2] (ab44)
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This product has been used in:
Wei Q et al. Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. Cancer Epidemiol Biomarkers Prev 14:1961-6 (2005). PubMed: 16103444
If you publish research using ab44 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to XPA
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XPA antibody [5A2] - more information
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XPA antibody [5A2] - related products:
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XPA antibody [5A2] - other tools:
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Contact Abcam with a Technical Enquiry about XPA antibody [5A2] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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