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Western blot - XPC antibody (ab21078)
(enlarge)
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Product Name
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XPC antibody
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See all XPC antibodies (4)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to XPC
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Immunogen
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Synthetic peptide from N-terminus of Human XPC conjugated to a carrier protein
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Reacts with
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Hu
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Specificity
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Recognises XPC
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at an assay dependent dilution. Detects a band of approximately 125 kDa (predicted molecular weight: 105 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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HeLa whole cell lysate
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Nucl. Excision Repair
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Relevance
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Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair. XPC may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C (XPC); also known as xeroderma pigmentosum III (XP3). XPC is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: None
Constituents: PBS, pH 7.2
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Purification notes
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Affinity purified with antigen.
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this XPC antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for XPC antibody images, references, products related to ab21078 and other tools.
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XPC antibody images:
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 Western blot - XPC antibody (ab21078)
Predicted band size : 105 kDa
Western blot image of human XPC from HeLa whole cell lysate detected using rabbit polyclonal anti XPC.
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Search PubMed (MEDLINE) for references to XPC
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XPC antibody - more information
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Customer reviews (feedback) regarding XPC antibody |
Customer FAQs regarding XPC antibody |
Protocols for XPC antibody |
Price and availability of products related to XPC antibody |
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XPC antibody - related products:
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XPC antibody - other tools:
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Contact Abcam with a Technical Enquiry about XPC antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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