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Products:Signal Transduction >> Metabolism >> Amino Acids
Overview
Product name
Anti-XPNPEP3 antibody
See all XPNPEP3 products (3) ...
Description
Mouse polyclonal to XPNPEP3
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length XPNPEP3 protein (Human) (NP_071381)
Positive control
Human liver tissue lysate and XPNPEP3 transfected 293T cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72641 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 57 kDa.
Target
Tissue specificity
Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
Involvement in disease
Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
Sequence similarities
Belongs to the peptidase M24B family.
Cellular localization
Mitochondrion.
Target information above from: UniProt accessionQ9NQH7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Aminopeptidase P3 antibody
- APP3 antibody
- NPHPL1 antibody
see all
Database links
- Entrez Gene: 63929 Human
- SwissProt: Q9NQH7 Human
- Unigene: 529163 Human
Anti-XPNPEP3 antibody images:
Western blot - XPNPEP3 antibody (ab72641)
Anti-XPNPEP3 antibody (ab72641) at 1/500 dilution + human liver tissue lysate at 25 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 57 kDa
Observed band size : 50 kDa (why is the actual band size different from the predicted?)
Western blot - XPNPEP3 antibody (ab72641)
All lanes : Anti-XPNPEP3 antibody (ab72641) at 1/500 dilution
Lane 1 : XPNPEP3 transfected 293T cell line lysate
Lane 2 : Non transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 57 kDa
Observed band size : 63 kDa (why is the actual band size different from the predicted?)
References for Anti-XPNPEP3 antibody (ab72641)
ab72641 has not yet been referenced specifically in any publications.
Publishing research using ab72641? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"