Anti-XRCC1 (phospho S461) antibody (ab84413)

Overview

• Product nameAnti-XRCC1 (phospho S461) antibodySee all XRCC1 primary antibodies ...
• Description
  Rabbit polyclonal to XRCC1 (phospho S461)
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region surrounding Serine 461 of Human XRCC1 (P18887)

• Positive controlHuman breast adenocarcinoma; Mouse squamous cell carcinoma.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Nucleotide metabolism
  • Purine and pyrimidine synthesis

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA Damage & Repair
  • Base Excision Repair

Applications

Target

• FunctionCorrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
• Sequence similaritiesContains 2 BRCT domains.
• Post-translational
  modificationsPhosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
  Sumoylated.
• Cellular localizationNucleus. Accumulates at sites of DNA damage.

Target information above from: UniProt accession P18887 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7515 Human
  • Entrez Gene: 22594 Mouse
  • Omim: 194360 Human
  • SwissProt: P18887 Human
  • SwissProt: Q60596 Mouse
  • Unigene: 98493 Human
  • Unigene: 4347 Mouse

• Alternative names
  DNA repair protein XRCC1 antibodyRCC antibodyX ray repair complementing defective repair in chinese hamster antibody

  X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibodyX ray repair complementing defective repair in chinese hamster cells 1 antibodyX ray repair cross complementing protein 1 antibodyX ray repair, complementing defective, repair in Chinese hamster antibodyX-ray repair cross-complementing protein 1 antibodyXRCC 1 antibodyXrcc1 antibodyXRCC1_HUMAN antibody

  see all

Anti-XRCC1 (phospho S461) antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - XRCC1 (phospho S416) antibody (ab84413)
  Immunohistochemistry analysis of two serial sections of formalin-fixed, paraffin-embedded Human breast adenocarcinoma, using 1/250 ab84413 followed by DAB staining. Left panel: mock phosphatase treated; Right panel: calf intestinal phosphatase-treated.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - XRCC1 (phospho S416) antibody (ab84413)
  Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma, using 1/250 ab84413 followed DAB staining.