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Anti-XRCC2 antibody [XRCC2 1G4/1] (ab20253)

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Overview

Product name

Anti-XRCC2 antibody [XRCC2 1G4/1]
See all XRCC2 products (5) ...

Description

Mouse monoclonal [XRCC2 1G4/1] to XRCC2

Specificity

This antibody is specfic to XRCC2, and does not recognise other paralogs.

Tested applications

WBmore details

Cross reactivity

Reacts with

Hamster, Human

Immunogen

Recombinant human denatured XRCC2 protein.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

XRCC2 1G4/1

Myeloma

Sp2/0-Ag14

Isotype

IgG1

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.

Applications

Show applications key

Our Abpromise guarantee covers the use of ab20253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Predicted molecular weight: 34 kDa.

Target

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Sequence similarities

Belongs to the RecA family. RAD51 subfamily.

Post-translational
modifications

Phosphorylated upon DNA damage, probably by ATM or ATR.

Cellular localization

Nucleus.

Target information above from: UniProt accessionO43543 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DNA repair protein XRCC2 antibody
  • X ray repair complementing defective repair in Chinese hamster cells 2 antibody
  • X ray repair cross complementing protein 2 antibody
  • X-ray repair cross-complementing protein 2 antibody
  • Xrcc2 antibody
  • XRCC2_HUMAN antibody
see all

Database links

References for Anti-XRCC2 antibody [XRCC2 1G4/1] (ab20253)

This product has been referenced in:

  • Gildemeister OSet al. Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C. J Biol Chem 284:31945-52 (2009). WB; Human.Read more (PubMed: 19783859) »
  • Nagaraju Get al. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol 29:4283-94 (2009). WB.Read more (PubMed: 19470754) »

See all 2 publications for this product

Publishing research using ab20253? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"