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Anti-XRCC2 antibody (ab58466)

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Overview

Product name

Anti-XRCC2 antibody
See all XRCC2 products (5) ...

Description

Rabbit polyclonal to XRCC2

Specificity

ab58466 detects endogenous levels of total XRCC2 protein.

Tested applications

IHC-P, ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Synthetic peptide derived from internal sequence of human XRCC2.

Positive control

IHC-P: Human lung carcinoma tissue.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Homologous Recomb.

  • Immunohistochemistry (Paraffin-embedded sections) - XRCC2 antibody (ab58466)Immunohistochemistry (Paraffin-embedded sections) - XRCC2 antibody (ab58466) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab58466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 1 Image

    IHC-P

     IHC-P: 1/50 - 1/100.

    IHC-P: 1/50 - 1/100.

  • ELISA

     ELISA: 1/10000

    ELISA: 1/10000

Target

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Sequence similarities

Belongs to the RecA family. RAD51 subfamily.

Post-translational
modifications

Phosphorylated upon DNA damage, probably by ATM or ATR.

Cellular localization

Nucleus.

Target information above from: UniProt accessionO43543 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DNA repair protein XRCC2 antibody
  • X ray repair complementing defective repair in Chinese hamster cells 2 antibody
  • X ray repair cross complementing protein 2 antibody
  • X-ray repair cross-complementing protein 2 antibody
  • Xrcc2 antibody
  • XRCC2_HUMAN antibody
see all

Database links

Anti-XRCC2 antibody images:

  Immunohistochemistry (Paraffin-embedded sections) - XRCC2 antibody (ab58466)

Immunohistochemistry (Paraffin-embedded sections) - XRCC2 antibody (ab58466)

Ab58466, at 1/50 dilution, staining paraffin embedded human lung carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.

References for Anti-XRCC2 antibody (ab58466)

ab58466 has not yet been referenced specifically in any publications.

Publishing research using ab58466? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"