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Product name
Y-27632 dihydrochloride
Description
Selective Rho kinase inhibitor
Biological description
Potent, selective Rho kinase inhibitor. (Ki values are 0.22, 0.30, 73, 25, >250 μM for ROCKI, ROCKII, PKCα, PKA and MLCK respectively). Muscle relaxant. Systemically active antinociceptive. Increases human embryonic stem (hES) cell survival, inhibiting apoptosis.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride
Molecular Weight
320.26
Chemical structure
Molecular formula
C14H21N3O.2HCl
CAS Number
146986-50-7
Solubility
Soluble in water to 100 mM
PubChem identifier
0
Storage instructions
Store at +4°C (desiccating conditions). Do not freeze.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Rho kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for Y-27632 dihydrochloride (ab120129)
This product has been referenced in:
- Tsutsui H et al. An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nat Commun 2:167 (2011).Read more (PubMed: 21266967) »
- Darenfed H et al. Molecular characterization of the effects of Y-27632. Cell Motil Cytoskeleton 64:97-109 (2007).Read more (PubMed: 17009325) »
See all 5 publications for this product
Publishing research using ab120129? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"