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Product name
Z-D(OMe)E(OMe)VD(OMe)-FMK
Description
Cell permeable caspase-3 inhibitor
Alternative names
- Caspase-3 Inhibitor
- Z-DEVD-FMK (cell permeable)
Biological description
A potent, cell-permeable, and irreversible inhibitor of caspase-3. Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
Purity
> 90%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
N-Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Molecular Weight
668.67
Chemical structure
Molecular formula
C30H41FN4O12
Solubility
Soluble in DMSO to 20 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Obesity >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Hypertension >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Heart disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Diabetes >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Cancer >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Pharmacology >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Pharmacology >> Enzymes >> Caspase
Biochemicals >> Chemical Type >> Bioactive peptides
References for Z-D(OMe)E(OMe)VD(OMe)-FMK (ab120488)
This product has been referenced in:
- Kugawa F et al. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol Pharm Bull 23:930-5 (2000).Read more (PubMed: 10963298) »
- Sepänniitty L [Introduction to the Pirkanmaa Midwifery College and its curriculum]. Katilolehti 97:4-8 (1992).Read more (PubMed: 1619848) »
See all 3 publications for this product
Publishing research using ab120488? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"