Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Z-VAD(OMe)-FMK
Description
Cell permeable, irreversible pan-caspase inhibitor
Alternative names
- Z-VAD-FMK (cell permeable)
Biological description
A cell-permeable, irreversible, pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. Therefore, when using with isolated, purified or recombinant caspase enzymes, pre-treatment with an esterase is required.
Purity
> 90%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
N-Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight
467.49
Chemical structure
Molecular formula
C22H30FN3O7
Solubility
Soluble in DMSO to 20 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Obesity >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Hypertension >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Heart disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Diabetes >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Cancer >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Pharmacology >> Signaling >> Apoptosis & cell cycle >> Caspase
Biochemicals >> Pharmacology >> Enzymes >> Caspase
Biochemicals >> Chemical Type >> Bioactive peptides
References for Z-VAD(OMe)-FMK (ab120487)
This product has been referenced in:
- Saeki K et al. Amyloid precursor protein binding protein Fe65 is cleaved by caspases during DNA damage-induced apoptosis. Biol Pharm Bull 34:290-4 (2011).Read more (PubMed: 21415543) »
- Farber A et al. A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice. J Vasc Surg 30:752-60 (1999).Read more (PubMed: 10514215) »
See all 3 publications for this product
Publishing research using ab120487? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"