Overview

  • Product name
    Z36
  • Description
    Novel inhibitor of Bcl-XL
  • Biological description
    Novel inhibitor of Bcl-XL. Binds to Bcl-XL and Bcl-2 with Kd values of 3.7 μM and 1.8 μM respectively. Inhibits cell proliferation and induces autophagic cell death. Does not induce apoptosis.
  • Purity
    > 98%

Properties

  • Chemical name
    1-[3-(Dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
  • Molecular weight
    393.50
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C23H24FN3O2
  • CAS Number
    1243148-19-7
  • PubChem identifier
    71311634
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 50mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COC3CCC4NCC(/C=C2/C1CC(F)CCC1N(CCCN(C)C)C2=O)C4C3
  • Source

    Synthetic

  • Research areas

    References for Z36 (ab141757)

    This product has been referenced in:

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