ZM 336372, c-Raf inhibitor (ab120428)
Key features and details
- Potent, selective c-Raf inhibitor
- CAS Number: 208260-29-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZM 336372, c-Raf inhibitor -
Description
Potent, selective c-Raf inhibitor -
Biological description
Potent, cell-permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
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CAS Number
208260-29-1 -
Chemical structure
Properties
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Chemical name
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide -
Molecular weight
389.45 -
Molecular formula
C23H23N3O3 -
PubChem identifier
5730 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc2cc(NC(=O)c1cccc(c1)N(C)C)ccc2C)c3ccc(O)cc3 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab120428 has not yet been referenced specifically in any publications.