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ZM 336372

Product code: ab120428 (formerly Asc-428)

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Overview

Product name

ZM 336372

Description

Potent, selective c-Raf inhibitor

Biological description

Potent, cell permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10 fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

Molecular Weight

389.45

Chemical structure

Chemical Structure

Molecular formula

C23H23N3O3

CAS Number

208260-29-1

Solubility

Soluble in DMSO to 100 mM

Storage instructions

Store at +4°C.

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Raf kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for ZM 336372 (ab120428)

This product has been referenced in:

  • Deming D  et al. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res 161:28-32 (2010).Read more (PubMed: 20031160) »
  • Kunnimalaiyaan M  et al. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 142:959-64; discussion 959-64 (2007).Read more (PubMed: 18063082) »

See all 3 publications for this product

Publishing research using ab120428? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"