Anti-ZBRK1 antibody (ab77085)
Key features and details
- Rabbit polyclonal to ZBRK1
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-ZBRK1 antibody -
Description
Rabbit polyclonal to ZBRK1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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ChIP Related Products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab77085 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (3) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 60 kDa.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 60 kDa. |
Target
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Function
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 8 C2H2-type zinc fingers.
Contains 1 KRAB domain. -
Cellular localization
Nucleus matrix. Associated with the nuclear matrix. - Information by UniProt
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Database links
- Entrez Gene: 234358 Mouse
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Alternative names
- KRAB zinc finger protein ZFQR antibody
- ZBRK1 antibody
- ZFQR antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab77085 has been referenced in 3 publications.
- Chen K et al. ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer. Oncotarget 6:6959-76 (2015). IF . PubMed: 25749518
- Calderon MR et al. Ligand-dependent corepressor contributes to transcriptional repression by C2H2 zinc-finger transcription factor ZBRK1 through association with KRAB-associated protein-1. Nucleic Acids Res 42:7012-27 (2014). ChIP . PubMed: 24829459
- Hallen L et al. The KRAB-containing zinc-finger transcriptional regulator ZBRK1 activates SCA2 gene transcription through direct interaction with its gene product, ataxin-2. Hum Mol Genet : (2010). WB, ChIP ; Human . PubMed: 20926453