Overview

  • Product nameA-412997 dihydrochloride
  • Description
    Highly selective D4 agonist
  • Biological descriptionHighly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.
  • Purity> 98%

Properties

    References for A-412997 dihydrochloride (ab120581)

    This product has been referenced in:
    • Woolley ML  et al. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. Behav Pharmacol 19:765-76 (2008). Read more (PubMed: 19020411) »
    • Browman KE  et al. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol Biochem Behav 82:148-55 (2005). Read more (PubMed: 16154186) »
    • Moreland RB  et al. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav 82:140-7 (2005). Read more (PubMed: 16153699) »

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