Overview

  • Product nameA 438079
  • Description
    Potent, competitive P2X7 receptor antagonist
  • Biological descriptionPotent, competitive P2X7 receptor antagonist (pIC50 = 6.5 nM). Shown to reduce pathological nociception.
  • Purity> 98%

Properties

  • Chemical name3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride
  • Molecular weight342.61
  • Chemical structureChemical Structure
  • Molecular formulaC13H9Cl2N5.HCl
  • CAS Number899507-36-9
  • PubChem identifier11688742
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.Clc3cccc(c2nnnn2Cc1cnccc1)c3Cl
  • Source

    Synthetic

  • Research areas

    References for A 438079 (ab120413)

    This product has been referenced in:
    • Marcellino D  et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm 117:681-7 (2010). Read more (PubMed: 20387084) »
    • Donnelly-Roberts DL & Jarvis MF Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol 151:571-9 (2007). Read more (PubMed: 17471177) »
    • McGaraughty S  et al. P2X7-related modulation of pathological nociception in rats. Neuroscience 146:1817-28 (2007). Read more (PubMed: 17478048) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120413.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"