Overview

  • Product nameA 769662
  • Description
    AMP-activated protein kinase activator
  • Biological descriptionPotent, reversible activator of AMP-activated protein kinase (AMPK) (EC50 = 0.8 μM). Directly activates native rat AMPK by mimicking the effects of AMP - it activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK. Shown to inhibit Na+-K+-ATPase at higher concentrations (IC50 = 57 μM) . Inhibits differentiation of adipocytes.
  • Purity> 99%

Properties

  • Chemical name6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • Molecular weight360.39
  • Chemical structureChemical Structure
  • Molecular formulaC20H12N2O3S
  • CAS Number844499-71-4
  • PubChem identifier54708532
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESOc1ccccc1c2ccc(cc2)c4csc3NC(=O)C(C#N)=C(O)c34
  • Source

    Synthetic

  • Research areas

    References for A 769662 (ab120335)

    This product has been referenced in:
    • Benziane B  et al. AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. Am J Physiol Cell Physiol 297:C1554-66 (2009). Read more (PubMed: 19828836) »
    • Guigas B  et al. Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life 61:18-26 (2009). Read more (PubMed: 18798311) »
    • Göransson O  et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282:32549-60 (2007). Read more (PubMed: 17855357) »

    See all 4 Publications for this product

    Product Wall

    Thank you for contacting us.

    Ideally the reconstituted A769662 will be fully active for one month at -20C as given in the datasheet. I am sorry we have not done the stability test at -80C so we will not be able confirm it. There are however so...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"