Overview

  • Product name
    A 803467
  • Description
    Selective NaV1.8 channel blocker
  • Biological description
    Selective blocker of NaV1.8 channels (IC50 = 8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC50 values =1 μM). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • McGaraughty S  et al. A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. J Pharmacol Exp Ther 324:1204-11 (2008). Read more (PubMed: 18089840) »
  • Jarvis MF  et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A 104:8520-5 (2007). Read more (PubMed: 17483457) »
  • Rush AM & Cummins TR Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels. Mol Interv 7:192-5, 180 (2007). Read more (PubMed: 17827438) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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