Overview

  • Product nameA 803467
  • Description
    Selective NaV1.8 channel blocker
  • Biological descriptionSelective blocker of NaV1.8 channels (IC50 = 8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC50 values =1 μM). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive.
  • Purity> 98%

Properties

    References for A 803467 (ab120282)

    This product has been referenced in:
    • McGaraughty S  et al. A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. J Pharmacol Exp Ther 324:1204-11 (2008). Read more (PubMed: 18089840) »
    • Jarvis MF  et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A 104:8520-5 (2007). Read more (PubMed: 17483457) »
    • Rush AM & Cummins TR Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels. Mol Interv 7:192-5, 180 (2007). Read more (PubMed: 17827438) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120282.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"