A 83-01 (DMSO solution, sterile-filtered) (ab146622)

Overview

  • Product name
    A 83-01 (DMSO solution, sterile-filtered)
  • Description
    Potent ALK4, 5 and 7 kinase inhibitor. TGF-β1 inhibitor.
  • Biological description
    Potent, selective TGF-β type I receptor ALK5, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.

    Also available as a solid (ab142092).
  • Purity
    > 98%

Properties

  • Chemical name
    3-(6-Methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
  • Molecular weight
    421.52
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C25H19N5S
  • CAS Number
    909910-43-6
  • PubChem identifier
    16218924
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in DMSO (5 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • King AJ  et al. ALK5 inhibition maintains islet endothelial cell survival but does not enhance islet graft revascularisation or function. Horm Metab Res 47:78-83 (2015). Read more (PubMed: 25429440) »
  • Klincumhom N  et al. Selective TGF-ß1/ALK inhibitor improves neuronal differentiation of mouse embryonic stem cells. Neurosci Lett 578:1-6 (2014). Read more (PubMed: 24923762) »
  • Sun X  et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem 78:1805-12 (2014). Read more (PubMed: 25351330) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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