Biological descriptionCell-permeable analog of arachidonic acid (ab120916). Widely used as an inhibitor of the 85-kDa cytosolic group IV phospholipase A2 (cPLA2) and calcium-independent group VI phospholipase A2 (iPLA2) (IC50 values are 1.5 and 6.0 μM, respectively) . In non-neural cells, also inhibits cyclooxygenase and acyltransferase activities.
Storage instructionsStore at -20°C. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSupplied in ethanol (5 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 12 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for AACOCF3 (Arachidonyl trifluoromethyl ketone) (ab120350)
This product has been referenced in:
Farooqui AA et al. Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev58:591-620 (2006).
Read more (PubMed: 16968951) »
Ackermann EJ et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem270:445-50 (1995).
Read more (PubMed: 7814408) »