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Product name
AACOCF3 (Arachidonyl trifluoromethyl ketone)
Description
Phospholipase-A2 inhibitor
Alternative names
- Arachidonyl trifluoromethyl ketone
Biological description
Cell permeable analogue of arachidonic acid. Widely used as an inhibitor of the 85-kDa cytosolic group IV phospholipase A2 (cPLA2) and calcium-independent group VI phospholipase A2 (iPLA2) (IC50 values are 1.5 and 6.0 μM respectively) . In non-neural cells, also inhibits cyclooxygenase and acyltransferase activities.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one
Molecular Weight
356.47
Chemical structure
Molecular formula
C21H31F3O
CAS Number
149301-79-1
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Phospholipase & Lipase >> Inhibitors
Biochemicals >> Chemical Type >> Lipid
Biochemicals >> Chemical Type >> Biochemicals
References for AACOCF3 (Arachidonyl trifluoromethyl ketone) (ab120350)
This product has been referenced in:
- Street IP et al. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32:5935-40 (1993).Read more (PubMed: 8018213) »
- Löwenadler B et al. Enhanced immunogenicity of recombinant peptide fusions containing multiple copies of a heterologous T helper epitope. Eur J Immunol 20:1541-5 (1990).Read more (PubMed: 1696895) »
See all 5 publications for this product
Publishing research using ab120350? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"