AACOCF3 (Arachidonyl trifluoromethyl ketone) (ab120350)

Overview

  • Product name
    AACOCF3 (Arachidonyl trifluoromethyl ketone)
  • Description
    Phospholipase-A2 inhibitor
  • Alternative names
    • Arachidonyl trifluoromethyl ketone
  • Biological description
    Cell-permeable analog of arachidonic acid (ab120916). Widely used as an inhibitor of the 85-kDa cytosolic group IV phospholipase A2 (cPLA2) and calcium-independent group VI phospholipase A2 (iPLA2) (IC50 values are 1.5 and 6.0 μM, respectively) . In non-neural cells, also inhibits cyclooxygenase and acyltransferase activities.

Properties

References

This product has been referenced in:
  • Farooqui AA  et al. Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol Rev 58:591-620 (2006). Read more (PubMed: 16968951) »
  • Ackermann EJ  et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem 270:445-50 (1995). Read more (PubMed: 7814408) »
  • Street IP  et al. Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2. Biochemistry 32:5935-40 (1993). Read more (PubMed: 8018213) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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