This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Applications

  • Application notesPeptide ELISA: antibody detection limit dilution: 1/1000.

    WB: Predicted molecular weight: 46 kDa.
    Preliminary experiments gave an approx 26-28 kDa band in human brain (Amygdala, Cerebellum, Hippocampus) lysates after 1 µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 49.1k Da according to NP_065843.3. The 26-28 kDa band was successfully blocked by incubation with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionHydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
    • Tissue specificityExpressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines.
    • Sequence similaritiesBelongs to the 'GDXG' lipolytic enzyme family.
    • Post-translational
      modifications
      N-glycosylated.
    • Cellular localizationMembrane. Microsome.
    • Target information above from: UniProt accession Q6PIU2 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • Arylacetamide deacetylase like 1 antibody
      • Arylacetamide deacetylase-like 1 antibody
      • NCEH antibody
      • Nceh1 antibody
      • NCEH1_HUMAN antibody
      • Neutral cholesterol ester hydrolase 1 antibody
      • Neutral cholesterol ester hydrolase antibody
      see all

    References for Anti-AADACL1 antibody (ab77486)

    ab77486 has not yet been referenced specifically in any publications.

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