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Overview

  • Product nameAnti-NAV3 antibody - N-terminalSee all NAV3 primary antibodies ...
  • Description
    Rabbit polyclonal to NAV3 - N-terminal
  • Tested applicationsWB, IHC-P, IHC-Fr more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide from the N terminal region of Mouse NAV3, conjugated to an immunogenic carrier protein.

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Whole serum
  • PurityWhole antiserum
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab101792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/300 - 1/2000. Predicted molecular weight: 256 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
IHC-P IHC-P: 1/300 - 1/2000. Antigen retrieval is recommended.
IHC-Fr IHC-Fr: 1/300 - 1/2000.

Target

  • FunctionMay regulate IL2 production by T-cells. May be involved in neuron regeneration.
  • Tissue specificityHighly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
  • Involvement in diseaseNote=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome. Translocation t(12;18)(q21;q21.2).
  • Sequence similaritiesBelongs to the Nav/unc-53 family.
    Contains 1 CH (calponin-homology) domain.
  • Developmental stageExpressed in fetal brain.
  • Cellular localizationNucleus outer membrane.

    • Target information above from: UniProt accession Q8IVL0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • FormThere are 3 isoforms produced by alternative splicing.
    • Alternative names
        KIAA0938 antibodyNAV 3 antibodyNAV3 antibody
        NAV3_HUMAN antibodyNeuron navigator 3 antibodyPOMFIL1 antibodyPore membrane and/or filament-interacting-like protein 1 antibodySteerin 3 antibodySteerin-3 antibodySTEERIN3 antibodyUnc 53 homolog 3 antibodyUnc-53 homolog 3 antibodyunc53H3 antibody
      see all

    References for Anti-NAV3 antibody - N-terminal (ab101792)

    ab101792 has not yet been referenced specifically in any publications.

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