IL33 protein (Active) (ab109164)
Our Abpromise guarantee covers the use of ab109164 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||FuncS: Use at an assay dependent dilution.|
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
- C9orf26CHROMOSOME 9 OPEN READING FRAME 26DKFZp586H0523
- DVS27DVS27 related proteinIL 1F11IL 33IL-1F11IL-33IL1F11IL33IL33_HUMANInterleukin 1 family member 11Interleukin 33INTERLEUKIN 33 NFHEVInterleukin 33 precursorInterleukin-1 family member 11Interleukin-33Interleukin33NF HEVNF-HEVNFEHEVNFHEVNuclear factor for high endothelial venulesNuclear factor from high endothelial venulesOTTHUMP00000021041RP11 575C20.2
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
modificationsProteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. Caspase-mediated proteolysis, once thought to activate IL33, rather acts as a switch to dampen its activity. Cathepsin G and elastase can cleave IL33 and generate highly active forms in activated neutrophils (IL-33(95-270), IL-33(99-270) and IL-33(109-270)). Proteolysis is not strictly required for biological activity.
References for IL33 protein (Active) (ab109164)
ab109164 has not yet been referenced specifically in any publications.