Anti-ARHGEF11 antibody (ab110059)

Overview

• Product nameAnti-ARHGEF11 antibodySee all ARHGEF11 primary antibodies ...
• Description
  Rabbit polyclonal to ARHGEF11
• SpecificityThis antibody detects endogenous levels of total ARHGEF11 protein.
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide derived from the N terminal region of Human ARHGEF11.

• Positive controlA549 and COLO cell extracts.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
  Note: PBS without Mg2+ and Ca2+
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab110059 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Regulators

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

Applications

Target

• FunctionMay play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
• Tissue specificityUbiquitously expressed.
• Sequence similaritiesContains 1 DH (DBL-homology) domain.
  Contains 1 PDZ (DHR) domain.
  Contains 1 PH domain.
  Contains 1 RGSL (RGS-like) domain.
• DomainThe poly-Pro region is essential for plasma membrane localization upon stimulation.
• Cellular localizationCytoplasm. Membrane. Translocated to the membrane upon stimulation.

Target information above from: UniProt accession O15085 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 9826 Human
  • Entrez Gene: 9826 Human
  • Entrez Gene: 213498 Mouse
  • Entrez Gene: 78966 Rat
  • Omim: 605708 Human
  • SwissProt: O15085 Human
  • SwissProt: O15085 Human
  • SwissProt: Q9ES67 Rat

  • Unigene: 516954 Human
  • Unigene: 160580 Rat

  see all

• Alternative names
  ARHGB_HUMAN antibodyARHGEF 11 antibodyARHGEF11 antibody

  DKFZp667F1223 antibodyGlutamate transporter EAAT4 associated protein 48 antibodyGTRAP 48 antibodyGTRAP48 antibodyKIAA0380 antibodyOTTHUMP00000038716 antibodyOTTHUMP00000038717 antibodyPDZ RHOGEF antibodyPDZ-RhoGEF antibodyRho guanine exchange factor (GEF) 11 antibodyRho guanine nucleotide exchange factor (GEF) 11 antibodyRho guanine nucleotide exchange factor 11 antibodyRhoA specific guanine nucleotide exchange factor antibodyRhoGEF glutamate transport modulator antibody

  see all

Anti-ARHGEF11 antibody images

• 

  Western blot - ARHGEF11 antibody (ab110059)
  All lanes : Anti-ARHGEF11 antibody (ab110059) at 1/500 dilution
  
  Lane 1 : A549 cell extract
  Lane 2 : COLO cell extract
  Lane 3 : COLO cell extract with immunizing peptide
  
  Lysates/proteins at 30 µg per lane.
  
  
  Predicted band size : 168 kDa