Anti-CD105 antibody [SN6] (ab11414)

Overview

• Product nameAnti-CD105 antibody [SN6]See all CD105 primary antibodies ...
• Description
  Mouse monoclonal [SN6] to CD105
• Specificityab11414 recognises the human CD105 cell surface antigen.
• Tested applicationsFlow Cyt, IHC-Fr, IP, WB, IHC-P, ICC/IF, IHC-FoFr more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Partially purified cell membrane antigens from fresh leukaemia cells. (Human).

• General notesThis product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• PurityProtein G purified
• Purification notesPurified IgG prepared by affinity chromatography.
• Clonality Monoclonal
• Clone numberSN6
• MyelomaP3-NS1/1-Ag4-1
• IsotypeIgG1
• Research Areas
  • Stem Cells
  • Endothelial Progenitors
  • Endothelial Markers

  • Stem Cells
  • Mesenchymal Stem Cells
  • Surface Molecules

  • Cancer
  • Tumor biomarkers
  • Other

  • Cardiovascular
  • Vasculature
  • Endothelium

  • Cardiovascular
  • Cardiovascular Markers
  • Cell Markers
  • Endothelial Cells

  • Immunology
  • Cell Type Markers
  • CD
  • Endothelial Cells

Applications

Target

• FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
• Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
• Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
• Cellular localizationMembrane.

Target information above from: UniProt accession P17813 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2022 Human
  • Omim: 131195 Human
  • SwissProt: P17813 Human
  • Unigene: 76753 Human

• Alternative names
  CD 105 antibodyCD105 antibodyCD105 antigen antibody

  EGLN_HUMAN antibodyEND antibodyEndoglin antibodyENG antibodyFLJ41744 antibodyHHT1 antibodyORW antibodyORW1 antibodyOsler Rendu Weber syndrome 1 antibodyRP11 228B15.2 antibodySN6 antibody

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Anti-CD105 antibody [SN6] images

• 

  Flow Cytometry - CD105 antibody [SN6] (ab11414)
  ab11414 staining CD105 in human KG1 cells by Flow Cytometry analysis.
• 

  Immunohistochemistry (Frozen sections) - Anti-CD105 antibody [SN6] (ab11414)This image is courtesy of an anonymous Abreview.
  ab11414 staining CD105 in Human breast tissue by Immunohistochemistry (Frozen sections). The sections were fixed in methanol prior to blocking with 10% serum for 5 minutes at 25°C. The primary antibody was diluted 1/200 and incubated with the sample for 1 hour. An HRP-conjugated goat anti-mouse polyclonal was used as the secondary antibody.
  Stains exclusively in the stroma - endothelium of the vessels - in human breast tissue. The image shows epithelial breast gland tissue surrounded by stroma.

  See Abreview