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Overview

  • Product nameDPYD protein (Human)See all DPYD proteins and peptides ...
  • Protein descriptionRecombinant full length Human DPYD (amino acids 1-173) with N terminal proprietary tag, 45.03kDa. (AAH08379)
  • Uniprot accessionQ12882
  • Molecular weight45.030kDa inclusive of tags
  • Protein length173 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number1.3.1.2
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Sequence notesMAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKH WKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCL KCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFAT ETLILAFSLMNHL
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114584 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. (Recombinant protein).

    Protein info

    • Alternative names
        DHPDHPDHaseDihydropyrimidine dehydrogenase
        Dihydropyrimidine dehydrogenase [NADP+]Dihydrothymine dehydrogenaseDihydrouracil dehydrogenaseDPDDPYDDPYD_HUMANMGC132008MGC70799OTTHUMP00000058954
      see all
  • FunctionInvolved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • Tissue specificityFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • PathwayAmino-acid biosynthesis; beta-alanine biosynthesis.
  • Involvement in diseaseDefects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • Sequence similaritiesBelongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • Cellular localizationCytoplasm.

    • Target information above from: UniProt accession Q12882 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    DPYD protein (Human) images

    • SDS-PAGE - DPYD protein (ab114584)
      SDS-PAGE - DPYD protein (ab114584)
      12.5% SDS-PAGE showing ab114584 at approximately 45.03kDa stained with Coomassie Blue.

    References for DPYD protein (Human) (ab114584)

    ab114584 has not yet been referenced specifically in any publications.

    Publishing research using ab114584 ? Please let us know so that we can cite the reference in this datasheet

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