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Overview

  • Product nameARSA protein (Human)See all ARSA proteins and peptides ...
  • Protein descriptionRecombinant full length Human ARSA (amino acids 1-507) with N terminal proprietary tag. Predicted MW 81.84 kDa (UniProt: P15289).
  • Uniprot accessionP15289
  • Molecular weight81.840kDa inclusive of tags
  • Protein length507 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number3.1.6.8
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Sequence notesMGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYG HPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM AGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLT CFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTA DNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPG HIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP LLLGTGKSPRQSLFFYPSYPDEVRGVFAVRSGKYKAHFFT QGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYN LLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARG EDPALQICCHPGCTPRPACCHCPDPHA
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab116931 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. Recombinant protein.
  • Application notesThis peptide can be used with studies using ab77586 and ab154300.

    • Protein info

    • Alternative names
        arsAARSA_HUMANarylsulfatase A
        Arylsulfatase A component CAs 2AS AAs2ASAAW212749C230037L18RikCerebroside-sulfatasemetachromatic leucodystrophyMGC125207MLDOTTHUMP00000196546OTTHUMP00000196548TISP73
      see all
  • FunctionHydrolyzes cerebroside sulfate.
  • Involvement in diseaseDefects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.
    Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
  • Sequence similaritiesBelongs to the sulfatase family.
  • Post-translational
    modifications    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
  • Cellular localizationLysosome.

    • Target information above from: UniProt accession P15289 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ARSA protein (Human) images

    • SDS-PAGE - ARSA protein (Human) (ab116931)
      SDS-PAGE - ARSA protein (Human) (ab116931)
      12.5% SDS-PAGE stained with Coomassie Blue showing ab116931 at approximately 81.84 kDa.

    References for ARSA protein (Human) (ab116931)

    ab116931 has not yet been referenced specifically in any publications.

    Publishing research using ab116931 ? Please let us know so that we can cite the reference in this datasheet

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