Overview
Product nameADAM2 protein (Human)See all ADAM2 proteins and peptides ...
Protein descriptionRecombinant full length Human ADAM2, isoform 2 (amino acids 1-716) with N terminal proprietary tag. Predicted MW 104.76 kDa (UniProt: Q99965-2).
Uniprot accessionQ99965-2
Molecular weight104.760kDa inclusive of tags
Protein length716 amino acids
Expression hostWheat germ
Properties
FormLiquid
Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Storage bufferpH: 8.00
Constituents: 0.3% Glutathione, 0.79% Tris HCl
Concentration information loading...
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Best used within three months from the date of receipt.
Sequence notesMWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEG IESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGI MKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIES RDLSFKLQSVEYNHMGSDTTVVAQKVFQLIGLTNAIFVSF NITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLV LRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHP RTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMN PEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDP FFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATC RFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCN GSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDT FGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADN LQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFAS DHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTD KCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSG NFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIF CVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab117063
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
|
Notes |
| WB |
WB: Use at an assay dependent concentration. Recombinant protein. |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent concentration. |
| ELISA |
ELISA: Use at an assay dependent concentration. |
Application notesThis peptide can be used with studies using ab169969.
Protein info
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Alternative names
A disintegrin and metalloproteinase domain 2ADAM 2ADAM metallopeptidase domain 2
Adam2ADAM2_HUMANAI323749Cancer/testis antigen 15CRYN1CRYN2CT15Disintegrin and metalloproteinase domain-containing protein 2Fertilin betaFertilin subunit betaFtnbPH 30PH 30bPH-30PH30Ph30 betaPH30-beta
see all
FunctionSperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Tissue specificityExpressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
Sequence similaritiesContains 1 disintegrin domain.
Contains 1 EGF-like domain.
Contains 1 peptidase M12B domain.
DomainA tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
Post-translational
modificationsThe prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
Cellular localizationMembrane.
ADAM2 protein (Human) images
References for ADAM2 protein (Human) (ab117063)
ab117063
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
SDS-PAGE - ADAM2 protein (Human) (ab117063)12.5% SDS-PAGE showing ab117063 at approximately 104.76 kDa.