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Overview

  • Product nameAnti-CD11a antibody [121/7]See all CD11a primary antibodies ...
  • Description
    Rat monoclonal [121/7] to CD11a
  • Tested applicationsNeutralising, Flow Cyt, Inhibition Assay more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    alpha chain of the integrin Lymphocyte Function-Associated Antigen-2 (LFA-1 or CD11a)

Properties

Applications

Our Abpromise guarantee covers the use of ab119356 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Neutralising Neut: Use at an assay dependent dilution.
Flow Cyt Flow Cyt: Use at an assay dependent dilution.
Inhibition Assay Inhib: Use at an assay dependent dilution.

Target

  • FunctionIntegrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
  • Tissue specificityLeukocytes.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
    Contains 1 VWFA domain.
  • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P20701 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibodyAntigen CD11A antibodyCD 11a antibody
        CD11 antigen-like family member A antibodyCD11a antibodyCD11a antigen antibodyIntegrin Alpha L antibodyIntegrin alpha-L antibodyIntegrin gene promoter antibodyIntegrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibodyITAL_HUMAN antibodyItgal antibodyITGAL protein antibodyLeukocyte adhesion glycoprotein LFA 1 alpha chain antibodyLeukocyte adhesion glycoprotein LFA-1 alpha chain antibodyLeukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibodyLeukocyte function associated molecule 1 alpha chain antibodyLeukocyte function-associated molecule 1 alpha chain antibodyLFA 1 alpha antibodyLFA 1 antibodyLFA 1A antibodyLFA-1A antibodyLFA1A antibodyLy15 antibodyLy21 antibodyLymphocyte function associated antigen 1 antibodyLymphocyte Function Associated Antigen Type 1 alpha antibodyp180 antibody
      see all

    References for Anti-CD11a antibody [121/7] (ab119356)

    This product has been referenced in:
    • Champe M  et al. Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a. J Biol Chem 270:1388-94 (1995). Read more (PubMed: 7530713) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"