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Overview

  • Product nameMTEP hydrochloride
  • Description
    Potent, selective mGlu5 antagonist
  • Biological descriptionBrain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).
  • Purity> 99%

    • Properties

  • Chemical name3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
  • Molecular Weight236.72
  • Chemical structureChemical Structure
  • Molecular formulaC11H8N2S.HCl
  • CAS Number1186195-60-7
  • PubChem identifier45073467
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCc2nc(C#Cc1cccnc1)cs2.Cl
  • Source

    Synthetic

  • Research Areas

    • References for MTEP hydrochloride (ab120035)

    This product has been referenced in:
    • Varty GB  et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) 179:207-17 (2005). Read more (PubMed: 15682298) »
    • Cosford ND  et al. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-6 (2003). Read more (PubMed: 12519057) »
    • Anderson JJ  et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473:35-40 (2003). Read more (PubMed: 12877935) »

    See all 14 Publications for this product

    Publishing research using ab120035 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"