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Overview

  • Product nameMMPIP
  • Description
    mGlu7 allosteric antagonist
  • Biological descriptionPotent, selective allosteric antagonist at mGlu7 receptors. Inhibits agonist-induced intracellular calcium mobilisation and cAMP accumulation (IC50 values are 26 and 610 nM). Also displays intrinsic activity; increasing forskolin-induced cAMP accumulation in the absence of an agonist. Exhibits no significant activity at mGluR1, mGluR2, mGluR3, mGluR4, mGluR5, and mGluR8. Also available in Kit: mGlu antagonists (ab120245)
  • Purity> 98%

    • Properties

  • Chemical name6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)isoxazolo[4,5-c]pyridin-4(5H)-one
  • Molecular Weight333.35
  • Chemical structureChemical Structure
  • Molecular formulaC19H15N3O3
  • CAS Number479077-02-6
  • PubChem identifier9945530
  • Storage instructionsStore at room temperature (desiccating conditions).
  • Solubility overviewSoluble in DMSO to 10 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCOc1ccc(cc1)C3=Cc2onc(c2C(=O)N3C)c4ccncc4
  • Source

    Synthetic

  • Research Areas

    • References for MMPIP (ab120245)

    This product has been referenced in:
    • Niswender CM  et al. Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol 77:459-68 (2010). Read more (PubMed: 20026717) »
    • Li X  et al. Metabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism. Neuropsychopharmacology 34:1783-96 (2009). Read more (PubMed: 19158667) »
    • Suzuki G  et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-56 (2007). Read more (PubMed: 17609420) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"