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AbcamBiochemicals (Asc-281)

Amiloride hydrochloride (ab120281)

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Overview

  • Product nameAmiloride hydrochloride
  • Description
    eNaC blocker
  • Biological descriptionEpithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.
  • Purity> 99%

    • Properties

  • Chemical nameN-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
  • Molecular Weight266.09
  • Chemical structureChemical Structure
  • Molecular formulaC6H8ClN7O.HCl
  • CAS Number2016-88-8
  • PubChem identifier16230
  • Storage instructionsStore at room temperature.
  • Solubility overviewSoluble in water to 10 mM (with heating) and in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCl.Clc1nc(C(=O)NC(=N)N)c(N)nc1N
  • Source

    Synthetic

  • Research Areas

    • References for Amiloride hydrochloride (ab120281)

    This product has been referenced in:
    • Dai XQ  et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol 72:1576-85 (2007). Read more (PubMed: 17804601) »
    • Alvarez de la Rosa D  et al. Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol 62:573-94 (2000). Read more (PubMed: 10845103) »
    • Frelin C  et al. Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie 70:1285-90 (1988). Read more (PubMed: 2852509) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"