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AbcamBiochemicals (Asc-314)

Furosemide (ab120314)

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Overview

  • Product nameFurosemide
  • Description
    Inhibitor of the Na+/2Cl-/K+ cotransporter. Also GABAA antagonist.
  • Biological descriptionInhibitor of the Na+/2Cl-/K+ cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABAA receptors displaying approx 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.
  • Purity> 99%

    • Properties

  • Chemical name5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid
  • Molecular Weight330.74
  • Chemical structureChemical Structure
  • Molecular formulaC12H11ClN2O5S
  • CAS Number54-31-9
  • PubChem identifier3440
  • Storage instructionsStore at room temperature.
  • Solubility overviewSoluble in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESNS(=O)(=O)c2cc(c(NCc1ccco1)cc2Cl)C(=O)O
  • Source

    Synthetic

  • Research Areas

    • References for Furosemide (ab120314)

    This product has been referenced in:
    • Guyon A  et al. Furosemide modulation of GABA(A) receptors in dopaminergic neurones of the rat substantia nigra. Neuropharmacology 43:750-63 (2002). Read more (PubMed: 12367620) »
    • Thompson SA  et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Mol Pharmacol 55:993-9 (1999). Read more (PubMed: 10347239) »
    • Romano G  et al. The site of action of furosemide. Pharmacol Res 37:409-19 (1998). Read more (PubMed: 9642037) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"