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Overview

  • Product nameO-1602
  • Description
    Potent, selective GPR55 agonist
  • Biological descriptionAnalogue of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC50 values are 13, > 30000 and > 30000 nM for GPR55, CB1 and CB2 receptors respectively). Inhibits mouse osteoclast formation in vitro, stimulates osteoclast polarization and resorption, causes activation of Rho and ERK1/2, and inhibits human neutrophil migration.
  • Purity> 98%
  • General notes

    Sold under license from Virginia Commonwealth University.

    • Properties

  • Chemical name5-Methyl-4-((1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-enyl)benzene-1,3-diol
  • Molecular Weight258.36
  • Chemical structureChemical Structure
  • Molecular formulaC17H22O2
  • CAS Number317321-41-8
  • PubChem identifier45073499
  • Storage instructionsStore at -20°C (desiccating conditions).
  • Solubility overviewSupplied in methyl acetate (10 mg/ml)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCC(=C)[C@@H]2CCC(C)=C[C@H]2c1c(C)cc(O)cc1O
  • Source

    Synthetic

  • Research Areas

    • References for O-1602 (ab120407)

    This product has been referenced in:
    • Whyte LS  et al. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A 106:16511-6 (2009). Read more (PubMed: 19805329) »
    • McHugh D  et al. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Mol Pharmacol 73:441-50 (2008). Read more (PubMed: 17965195) »
    • Ryberg E  et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 152:1092-101 (2007). Read more (PubMed: 17876302) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"