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AbcamBiochemicals (Asc-581)

A-412997 dihydrochloride (ab120581)

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Overview

  • Product nameA-412997 dihydrochloride
  • Description
    Highly selective D4 agonist
  • Biological descriptionHighly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood brain barrier following systemic administration.
  • Purity> 98%

    • Properties

  • Chemical nameN-(3-Methylphenyl)-2-[4-(2-pyridinyl)-1-piperidinyl]acetamide dihydrochloride
  • Molecular Weight382.33
  • Chemical structureChemical Structure
  • Molecular formulaC19H23N3O.2HCl
  • CAS Number630116-49-3
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in water to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for A-412997 dihydrochloride (ab120581)

    This product has been referenced in:
    • Woolley ML  et al. Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat. Behav Pharmacol 19:765-76 (2008). Read more (PubMed: 19020411) »
    • Browman KE  et al. A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats. Pharmacol Biochem Behav 82:148-55 (2005). Read more (PubMed: 16154186) »
    • Moreland RB  et al. A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav 82:140-7 (2005). Read more (PubMed: 16153699) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"