You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.
AbcamBiochemicals (Asc-753)

Clonidine hydrochloride (ab120753)

Submit a Question

Overview

  • Product nameClonidine hydrochloride
  • Description
    α2 adrenoceptor agonist
  • Biological descriptionα2 adrenoceptor agonist. pKi values are 6.3, 7.5, 7.5 and 6.0 for α1, α2 adrenoceptors, I1 and I2 imidazoline receptors respectively. Anti-hypertensive, sedative and analgesic activity in vivo. Centrally active following oral administration.
  • Purity> 99%

    • Properties

  • Chemical nameN-(2,6-Dichlorophenyl)-4,5-dihydro-1H-Imidazol-2-amine hydrochloride
  • Molecular Weight266.56
  • Chemical structureChemical Structure
  • Molecular formulaC9H9Cl2N3.HCl
  • CAS Number4205-91-8
  • Storage instructionsStore at +4°C.
  • Solubility overviewSoluble in water to 100 mM and in DMSO to 75 mM (with warming)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for Clonidine hydrochloride (ab120753)

    This product has been referenced in:
    • Millan MJ  et al. S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. J Pharmacol Exp Ther 295:1192-205 (2000). Read more (PubMed: 11082457) »
    • Silva EG  et al. Dual effect of clonidine on mesenteric artery adrenoceptors: agonistic (alpha-2) and antagonistic (alpha-1). J Pharmacol Exp Ther 277:872-6 (1996). Read more (PubMed: 8627569) »
    • Atlas D & Sabol SL Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase. Eur J Biochem 113:521-9 (1981). Read more (PubMed: 6260485) »

    See 0 Publications for this product

    Publishing research using ab120753 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit a Question for ab120753

    There are currently no Questions for ab120753.
    Please use the link above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"