Anti-Aquaporin 3 antibody (ab125045)

Overview

• Product nameAnti-Aquaporin 3 antibodySee all Aquaporin 3 primary antibodies ...
• Description
  Rabbit polyclonal to Aquaporin 3
• Tested applicationsWB, ICC/IF more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  Predicted to work with: Rabbit, Horse
• Immunogen

  Synthetic peptide: N-CHLEQPPPSTEAENVKLAHMKHKEQI, corresponding to C terminal amino acids 267-292 of Rat Aquaporin 3 (NP_113891.1).

  Run BLAST with Run BLAST with
• Positive controlRat kidney tissue; Rat kidney lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at -20ºC.
• Storage bufferpH: 7.40
  Preservative: 0.09% Sodium azide
  Constituents: 49% PBS, 50% Glycerol
• Concentration information loading...
• PurityProtein A purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

Applications

Target

• FunctionWater channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
• Tissue specificityWidely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.
• Sequence similaritiesBelongs to the MIP/aquaporin (TC 1.A.8) family.
• DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
• Cellular localizationBasolateral cell membrane. In collecting ducts of kidney.

Target information above from: UniProt accession Q92482 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 100053851 Horse
  • Entrez Gene: 360 Human
  • Entrez Gene: 11828 Mouse
  • Entrez Gene: 65133 Rat
  • Omim: 600170 Human
  • SwissProt: Q92482 Human
  • SwissProt: Q8R2N1 Mouse
  • SwissProt: P47862 Rat

  • Unigene: 234642 Human
  • Unigene: 34043 Mouse
  • Unigene: 11109 Rat

  see all

• Alternative names
  AQP 3 antibodyAQP-3 antibodyAqp3 antibody

  AQP3_HUMAN antibodyAquaglyceroporin-3 antibodyAquaporin 3 (GIL blood group) antibodyAquaporin 3 (Gill blood group) antibodyAquaporin-3 antibodyAquaporin3 antibodyGIL antibodyGill blood group antibody

  see all

Anti-Aquaporin 3 antibody images

• 

  Immunocytochemistry/ Immunofluorescence - Anti-Aquaporin 3 antibody (ab125045)
  ab125045, at 1/200 dilution, staining Aquaporin 3 in Rat kidney tissues by Immunofluorescence.
• 

  Western blot - Anti-Aquaporin 3 antibody (ab125045)
  All lanes : Anti-Aquaporin 3 antibody (ab125045) at 1/2000 dilution
  
  Lane 1 : Rat kidney lysate
  Lane 2 : Rat kidney lysate
  Lane 3 : Rat kidney lysate
  Lane 4 : Rat kidney lysate
  
  
  Predicted band size : 31 kDa