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Overview

  • Product nameAnti-5T4 antibodySee all 5T4 primary antibodies ...
  • Description
    Rabbit polyclonal to 5T4
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 168-197 of Human 5T4 (NP_001159864.1, NP_006661.1).

  • Positive controlA2058 cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab130522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/100 - 1/500. Predicted molecular weight: 46 kDa.

Target

  • Tissue specificityExpressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
  • Sequence similaritiesContains 6 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q13641 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Form5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60 (Ward et al., 2006).
    • Alternative names
        5T4 antibody5T4 oncofetal antigen antibody5T4 oncofetal trophoblast glycoprotein antibody
        5T4 oncotrophoblast glycoprotein antibody5T4AG antibodyAW495680 antibodyM6P1 antibodyTPBG antibodyTPBG_HUMAN antibodyTrophoblast glycoprotein antibody
      see all

    Anti-5T4 antibody images

    • Western blot - Anti-5T4 antibody (ab130522)
      Western blot - Anti-5T4 antibody (ab130522)
      Anti-5T4 antibody (ab130522) at 1/100 dilution + A2058 cell line lysate at 35 µg

      Predicted band size : 46 kDa

    References for Anti-5T4 antibody (ab130522)

    ab130522 has not yet been referenced specifically in any publications.

    Publishing research using ab130522 ? Please let us know so that we can cite the reference in this datasheet

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